Arsenal make the trip to St Mary's Stadium after suffering a disappointment in their mission to finish in the top four this season last weekend.
The Gunners were defeated 2-1 at home by Brighton, a terrible result that puts them three points behind Tottenham Hotspur, but they do have a game in hand.
Arsenal lost 3-0 at Crystal Palace the week before their home loss to Brighton, and they cannot afford a repeat performance in this game otherwise the top four will be out of reach.
Arsenal has won five of their past six Premier League matches on the road. Leeds United, Norwich City, Wolverhampton Wanderers, Watford, and Aston Villa have all won.
Arsenal has gone undefeated in 21 of their previous 24 Premier League games against Southampton and has scored 1 or more goals in each of their last 11 meetings with the Saints.
Southampton's striker Armando Broja may be unavailable owing to personal reasons. They also have concerns about Shane Long, Lyanco Vojnovic, and Alex McCarthy's fitness.
The injured trio of Thomas Partey, Kieran Tierney, and Takehiro Tomiyasu are slated to miss the game. They also have reservations about Emile Smith Rowe's fitness.
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