Following a run of positive outcomes, Southampton has shifted into the top half of the table. Now at the tenth a point clear of Aston Villa.
Manchester United stand sixth one point outside the top four and 11 points above Southampton.
Man Utd went on a 1-1 level against Burnley in midweek, despite celebrating 65% possession and racking up 22 shots.
Paul Pogba gave the Red Devils the lead after 18 minutes, while the travellers had a further two goals ruled out.
Jay Rodriguez levelled for the hosts just after the break.
Southampton raced to grab an outstanding 3-2 victory at the Tottenham Hotspur Stadium on Wednesday.
Southampton deserved to bag all three points after having the majority of attempts.
Saints are celebrating a positive rush at the moment, with just one loss coming in their past seven league matches.
The match will be live on supersport premier league and beIN sports channels.